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Discovered in the 1960s, selegiline is a selective MAO-B inhibitor that slows the brain’s breakdown of dopamine, easing motor symptoms for some people with Parkinson’s disease. Today it is widely used, often as an add-on to levodopa or in specific depressive regimens, and it is available in oral and transdermal forms.

What Selegiline is and how it works

Selegiline blocks monoamine oxidase B, the enzyme that breaks down dopamine in the brain. This raises dopamine levels and can improve motor function in Parkinson’s disease.

At low doses it mainly inhibits MAO-B and spares MAO-A, which reduces the risk of dietary interactions; at higher doses or certain formulations MAO-A inhibition can occur, raising tyramine-related concerns. The available forms include oral tablets and a transdermal patch; the patch delivers steadier exposure with fewer peak effects.

Common medical uses

In Parkinson’s disease, selegiline is used as an early monotherapy in some patients and as an adjunct to levodopa in others to enhance effect and extend the benefit of levodopa.

For mood disorders, selegiline is used in select regimens. The transdermal patch formulation is approved in some regions for major depressive disorder and is sometimes used when other antidepressants do not fully control symptoms.

How it is typically taken

Oral selegiline comes as tablets and orally disintegrating tablets. Dosing varies by condition and formulation and should follow a clinician’s plan.

The transdermal patch is applied to clean, dry skin once daily. Place it on a non-irritated area and rotate sites. Do not apply heat to the patch, and remove before bathing or swimming as directed by a clinician.

Important safety information

Selegiline can interact with other antidepressants and certain pain and stimulant medicines, increasing the risk of serotonin syndrome or hypertensive reactions. Tell your provider about all medicines you take, including over-the-counter drugs and supplements.

Dietary cautions vary by formulation. While the patch carries fewer dietary restrictions than older oral forms, follow your clinician’s guidance. Avoid use with other MAO inhibitors unless directed by a clinician, and discuss health conditions such as liver disease, glaucoma, or severe hypertension before starting therapy.

Common side effects

Possible effects include nausea, dizziness, dry mouth, and insomnia. Headache and fatigue may occur, along with minor confusion in some people.

Patch-related skin reactions—redness, itching, or irritation—can develop at the application site. Other less common effects include lightheadedness, constipation, or changes in blood pressure.