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Glimepiride is an oral sulfonylurea that increases pancreatic insulin secretion by blocking ATP-sensitive potassium channels in beta cells. It lowers fasting and postprandial glucose and HbA1c. Onset 2-4 hours; duration up to 24 hours. Metabolized by CYP2C9; excreted in urine/feces. Contraindicated in type 1 diabetes or DKA; watch hypoglycemia risk and hepatic/renal impairment.
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