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What Salmeterol + Fluticasone is

If you have persistent wheezing, shortness of breath, chest tightness, or coughing that keeps returning, you may have asthma or COPD symptoms that stay active. Salmeterol + Fluticasone is a prescription inhaled medicine that combines two drugs to help reduce these ongoing symptoms. It is a maintenance medicine, not a rescue inhaler.

Salmeterol is a long-acting bronchodilator. Fluticasone is an inhaled corticosteroid. Together, they help keep airways open and lower swelling when you use them regularly.

What it is used for

This medicine is used for long-term control of asthma in people who need both a bronchodilator and an inhaled steroid, and for maintenance treatment of COPD in adults. It helps prevent flare-ups and improves breathing during daily use. It is not for treating sudden, severe breathing problems. If symptoms worsen, use a fast-acting inhaler and seek medical help.

Use exactly as your doctor prescribes. Do not change the dose yourself. Regular use is important for best effect.

Contraindications and precautions

• Do not use if you are allergic to salmeterol, fluticasone, or any ingredient in the inhaler.
• Do not use as a rescue medicine for an acute asthma attack or COPD flare-up.
• Do not use in children unless a doctor supervises, and follow age-related guidance.
• Tell your doctor if you have active infections, especially systemic fungal infections or untreated tuberculosis.
• Inhaled steroids can cause thrush (mouth or throat infection). Rinse your mouth with water after each use and spit it out.
• Tell your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Rash, facial swelling, or other signs of a severe allergic reaction require urgent care.
• Long-term inhaled steroids may affect growth in children and may raise eye problems in some people. Regular check-ins with your clinician help manage risks.
• Avoid stopping suddenly. Your doctor may adjust dose gradually.

Side effects by frequency

• Very common: throat irritation, hoarseness, coughing.
• Common: headache, runny or stuffy nose, sore throat; thrush in the mouth or throat if you don’t rinse after use.
• Uncommon: palpitations or fast heartbeat, tremor, dizziness, mild upset stomach.
• Rare: rash or swelling from an allergic reaction; paradoxical worsening of breathing; severe allergic symptoms.
• Long-term inhaled steroids may slightly slow growth in children and have a small effect on eye health; discuss with your doctor if this concerns you.

Interactions with other substances

• Beta-blockers (like propranolol) can reduce the breathing-relief effect of salmeterol and may worsen symptoms.
• Other beta-agonists or stimulants can increase heart or nervous system side effects.
• CYP3A4 inhibitors (examples: ketoconazole, itraconazole, ritonavir, cobicistat) can raise fluticasone levels in your blood, increasing the risk of systemic side effects.
• Macrolide antibiotics (like erythromycin, clarithromycin) may raise salmeterol exposure and side effects.
• Tell your doctor about all medicines you take, including OTC drugs and herbal products, to assess possible interactions.
• Avoid starting new medicines without medical advice if you are using this inhaler, as some combinations may require dose adjustments.