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Dapsone

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Disclaimer: This page provides information about Aczone (dapsone gel 5%). It is not a substitute for professional medical advice.

What Aczone is

Aczone is a topical gel that contains the medicine dapsone. It is used on the skin to help treat acne. The gel is applied directly to the affected areas, usually the face, to reduce redness and swelling.

The medicine works mainly where acne forms, aiming to calm skin irritation and limit the active bacteria involved in pimples. It is designed to stay on the skin and act locally, rather than circulating through the body.

In the United Kingdom, Aczone may be prescribed by a clinician and should be used as directed. Your pharmacist can explain how to use it safely with your other skincare routines. Always follow the leaflet that comes with the medicine.

The gel form makes it easy to apply a thin layer to affected areas. It is not a soap or wash; it stays on the skin after you apply it. If you have questions about how it works for you, ask your pharmacist or doctor for guidance.

What Aczone treats

Aczone is aimed at inflammatory acne, where you see red, swollen spots and pustules. It can help reduce the size and redness of these lesions over time. It is not a cure for all types of acne, but it can be a helpful part of a broader treatment plan.

It may be used when basic skincare alone has not fully cleared the acne. In some cases your clinician will combine it with other acne treatments, depending on your skin and how it responds. It is important to use it as advised and not to overuse the product.

The gel targets skin irritation related to acne and can be suitable for adults and older teenagers, depending on medical history. Your clinician will consider any skin sensitivities or other conditions before starting treatment. If you have questions about suitability, talk to your pharmacist or doctor.

Your skin type and the location of the acne can influence how well Aczone works. It is typically part of a personalized plan rather than a one-size-fits-all solution. If you notice little or no improvement after several weeks, discuss this with your clinician to adjust your approach safely.

Practical steps to start using Aczone

Before you start, read the patient leaflet and talk to your clinician about your medical history and any other medicines you use. Tell them if you have heard of dapsone before or if you have reactions to similar medicines. This helps reduce the chance of a skin reaction or other problems.

Your skin should be clean and dry before applying Aczone. Use a gentle cleanser and pat the skin dry with a clean towel. Do not apply it to broken or irritated skin unless your clinician has advised you otherwise.

Apply a thin layer only to the acne-affected areas. Avoid healthy skin, eyes, mouth, and inside the nose. Do not rub the gel in; let it sit on the surface and dry naturally. If you wear makeup, wait until the gel has dried before applying it on top.

Wash your hands after applying the gel to prevent transfer to other areas, such as the eyes or mouth. If you accidentally get gel in your eyes, rinse with clean water and seek medical advice if irritation continues. Keep the product away from open flames or heat sources as instructed in the leaflet.

Step 1: Prepare your skin

Use a mild, non-irritating cleanser and lukewarm water. Gently pat your skin dry with a clean towel. Avoid scrubbing hard, which can irritate the skin.

Step 2: Apply a thin layer to the affected areas

Dot the gel onto the pimples or affected zones and spread in a thin layer. You should not use thick coats or apply to large areas beyond what is needed for acne.

Step 3: Let it dry and avoid rubbing in or washing immediately

Allow the gel to dry completely before applying moisturisers, sunscreen, or makeup unless your clinician has advised otherwise. Follow the leaflet’s guidance on how long to wait before other products are applied.

Step 4: Build into your routine with care

If you are using other acne products, introduce Aczone gradually or as advised by your clinician. Some combinations can irritate the skin, so a tailored plan is best. If you notice unusual irritation, pause use and speak to your pharmacist or doctor.

Using Aczone daily

For most people, a thin layer to the affected areas is applied once daily. Your clinician will confirm the exact routine for you. Do not exceed the recommended amount, as this can increase the chance of skin irritation.

Consider a daily skincare routine that is gentle on the skin. Use non-abrasive cleansers and avoid harsh exfoliants when you are starting Aczone. If you use other acne medicines, your clinician may adjust the order or timing of applications.

About timing, some people prefer to apply Aczone at a time when it will have time to dry before sleep or other routines. If you are outdoors, you can apply sunscreen afterwards if advised by your clinician. Always keep the gel away from eyes and mucous membranes.

Missed doses: if you forget a daily application, apply it as soon as you remember unless it is near your next planned dose. Do not double up to make up for a missed application. If you are unsure what to do, contact your pharmacist for guidance.

Step 5: Combining Aczone with skincare products

Usually it can be used with standard moisturisers and sunscreen, but some combinations may irritate the skin. If you are unsure, discuss a suitable routine with your pharmacist or clinician. When starting a new product, introduce it slowly to watch for irritation.

Step 6: What to avoid during treatment

Avoid applying Aczone to sunburned skin or raw wounds. Do not apply immediately after waxing or shaving in the treated areas if this causes irritation. If you have a history of skin sensitivity, let your clinician know so they can tailor the plan.

What to expect in the early days and weeks

Some people notice improvements within a few weeks, while for others it may take longer. The full effect is not immediate and depends on your skin response. If your acne does not improve after several weeks, discuss this with your clinician.

Your skin might feel dry, tight, or mildly irritated at first. This can improve as your skin adjusts to the medicine. If irritation becomes noticeable or persistent, you should seek advice from your pharmacist or doctor.

During the first weeks, you should continue with your regular skincare routine unless your clinician advises changes. Do not discontinue Aczone without talking to a professional, even if you feel it is not helping yet.

If you notice signs of a more serious skin reaction, such as swelling, widespread redness, blistering, or a painful rash, seek medical help promptly. Your clinician may adjust your treatment plan if needed.

When to contact a clinician during treatment

Call your clinician if you develop itching, swelling, or a widespread rash after starting Aczone. These could be signs of a reaction that needs assessment. Report any unusual or severe skin changes promptly.

If you have any new or worsening skin symptoms, or if you are pregnant or planning pregnancy, talk to your clinician before continuing. They can advise on the best approach for you.

Let your clinician know if you have a history of sulfa allergies or if you are taking other medicines that could interact with topical dapsone. They may adjust your plan accordingly. Seek urgent medical help if you experience trouble breathing, swelling of the face or lips, or throat tightness.

For dental or medical procedures, tell your healthcare team you are using Aczone. This helps them plan any skin-related care or procedure considerations if needed. Your pharmacist is also a good point of contact for day-to-day questions.

Storage and handling

Keep Aczone in its original packaging and store at room temperature, away from heat and direct light. Do not freeze the gel. Keep out of reach of children and pets.

Always check the expiry date on the packaging and discard any gel that has passed this date. If the product changes color or texture, do not use it and consult your pharmacist for guidance.

Do not share your Aczone with others, even if their symptoms look similar. Only use it as prescribed for your own skin condition. If you need to travel with the gel, keep it in a secure container and carry any necessary documentation.

If you accidentally apply too much or get gel in your eyes, rinse with plenty of clean water and seek medical advice if irritation persists. Keep products that come in contact with skin separate from pets or children to prevent accidental use or ingestion.

Side effects, warnings and who should not use Aczone

Common skin-related side effects include mild burning, itching, redness, or dryness at the application site. These usually improve with time as your skin adjusts. If the irritation is bothersome or persistent, talk to your pharmacist or clinician.

Severe allergic reactions are rare but require urgent medical care. Seek urgent medical help if you notice swelling of the lips, tongue, or face, severe skin rash, or trouble breathing after applying the product.

Avoid using Aczone if you have a known allergy to dapsone or other sulfonamide medicines. Tell your clinician about any drug allergies before starting treatment. Women who are pregnant or breastfeeding should discuss the risks and benefits with their clinician before starting this gel.

Aclarl: The decision to use Aczone may depend on local rules and your individual health. If you are unsure whether this medicine is suitable for you, consult your pharmacist or doctor. They can explain how it fits with your overall acne plan and other medications.

Who should not use Aczone

Do not start Aczone if you have a known allergy to dapsone or related medicines. If you have a history of severe skin reactions to topical products, discuss alternatives with your clinician.

If you are pregnant, planning pregnancy, or breastfeeding, talk to your clinician before using Aczone. You may be advised to choose a different treatment or to adjust your plan carefully.

People with certain medical conditions or on specific medicines should be assessed by a clinician before use. Always share your full medical history and current medicines with the pharmacist or doctor when being considered for this treatment. If in doubt, consult your clinician for tailored advice.

Frequently asked questions about Aczone

Below are practical answers to common questions. If you need more help, your pharmacist or clinician can provide personalised guidance.

Can I travel with Aczone in my bag?

Yes, you can take Aczone with you when you travel. Keep it in its original packaging and carry any needed prescription information. If you are flying, follow the airline rules for liquids and gels.

What happens if I apply Aczone at the wrong time of day?

A single late application is unlikely to cause harm, but try to stay on a regular schedule. If you frequently miss applications, talk to your clinician about how to adjust your routine safely.

Is it safe to use Aczone with other acne medicines?

Many people use Aczone alongside other acne treatments. Start slowly with new products to minimise irritation, and always use products as advised by your clinician. If you notice increased redness or burning, seek guidance.

How long before I see an improvement?

Improvements are variable. Some people notice changes within a few weeks, while others may take longer. If there is no improvement after several weeks, discuss adjustments with your clinician.

Can I split, crush, or dilute Aczone gel?

No. Do not alter the gel’s form or mix it with other substances unless your clinician specifically tells you to. Altering the preparation can change how it works and may increase irritation.

Should I tell my dentist I use Aczone?

Yes, tell your dentist you are using Aczone. They should know all medicines you use, especially if they plan skin-related procedures or antiseptic products that contact the skin.

Can I use Aczone during pregnancy?

Discuss with your clinician. They will weigh the benefits and potential risks for you and your baby. Do not start new skin medicines without professional advice during pregnancy.

Can I drink alcohol while using Aczone?

Alcohol does not have a direct, well-known interaction with Aczone. However, alcohol can worsen acne for some people or irritate the skin. Use moderation and monitor how your skin responds.

Is Aczone suitable for teens?

It can be prescribed to adolescents when acne is present and a clinician determines it is appropriate. Age, skin type, and medical history are all considered in the decision.

What should I do if I get Aczone on my clothing or surfaces?

Rinse or wipe off fresh spills with a clean cloth and water. Do not rub in or attempt to remove dried gel with soap, as advised by your clinician. Proper storage helps prevent accidental contact.

What if I have a skin reaction after applying Aczone?

Light skin reactions are common and often temporary. If the reaction is severe, persistent, or spreading, contact your clinician promptly. Do not continue using the product if you suspect an allergic reaction.

Can Aczone be used on other parts of the body?

It is usually used on the face, but your clinician may prescribe it for other affected areas. Follow their advice exactly for any non-facial use and report any skin changes to them.

Will Aczone affect my skin under a sunscreen or makeup?

Most people can use sunscreen or makeup over Aczone once it has dried. If you experience stinging or burning with any product, pause and discuss alternatives with your clinician.

Do I need a prescription to get Aczone in the UK?

Aczone may require a prescription depending on local rules. Check with your pharmacist or clinician about how you will obtain the medicine in your area. Do not use it without professional guidance if you are unsure.

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Airmail

14–21 days. Free from £149.53 .

Express delivery

5–9 days. £22.43

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−10% when paying with cryptocurrency.

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Reorder discount

−10% on all repeat orders.

📦 Packaging and discretion

All orders are packed in neutral, unbranded boxes with no product name on the outside.

Adam Wilkinson
Medically reviewed by
Adam Wilkinson
Registered Pharmacist (UK), MPharm